the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

background and objective: p53 is a suppressive gene that plays a key role in dna repair and apoptosis. the purpose of this study was to investigate the effect of p53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (scc) response to neoadjuvant chemoradiotherapy. patients and methods: in this retrospective cohort study, 44 patients with loca...

introdouction: squamous cell carcinoma is the most common oral cancer and the prognosis because of a late diagnosis remains poor despite numerous treatments. therefore, we conducted a cross-sectional study to investigate the relationships between survival rate(sr) of oral squamous cell carcinoma (oscc) and clinical,demographic, pathological, and molecular factors in yazd city during 1998– 2008....

conclusions despite the fact that abnormalities in p53 and p27kip1 may be involved in the development of oscc, their clinical significance in the studied population seems limited. further investigation on the combined p53/p27kip1 expression may be helpful in predicting the biologic behavior of this tumor. results p53 and p27kip1 expression were found in 28.57% (8 positive versus 20 negative) an...

the p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms.the transcription factor p63 is a homologue of the tumor suppressor p53. unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63, , is transcribed from two different promoters giving rise...

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...

The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...

in this archival analysis of genetic & protein alterations in the p53 tumor suppressor gene, we used immunohistochemical methods for detection of these alterations. the tumor series includes: 61 paraffin embedded esophageal squamous cell carcinoma from a high incidence (ethnic) & a non-high incidence regions in iran.

background there is evidence of a possible etiological role of human papillomaviruses (hpvs) in the development of colorectal cancer. loss of p53 tumor suppressor gene function has been found in many malignancies and it can occur in a variety of ways, including gene mutation and interaction with the e6 protein of oncogenic hpvs. the objective of this study was to determine the prevalence of hpv...